Related Experiment Video
Updated: May 26, 2026

07:58
Characterizing Mutational Load and Clonal Composition of Human Blood
Published on: July 11, 2019
Clonal ancestry in AML: insights from founding genetic events
Zhi Han Yeoh1,2, Ing Soo Tiong1,3,4
1Department of Clinical Haematology, Peter MacCallum Cancer Centre & Royal Melbourne Hospital, Melbourne, Australia.
Leukemia & Lymphoma
|May 25, 2026
Summary
No abstract available in PubMed .
Related Concept Videos
Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Lineage Commitment
Commitment is the process whereby stem cells:
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...

