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Related Concept Videos

Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

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Related Experiment Video

Updated: May 26, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Total artificial hearts: an evolution on the horizon.

Ajith Nair1, Niels P van der Kaaij2, Jolanda Kluin2

  • 1The Texas Heart Institute at Baylor College of Medicine, 6770 Bertner Ave, MC 3-116, Houston, TX 77030, USA.

European Heart Journal
|May 25, 2026
PubMed
Summary

Mechanical blood pumps, including total artificial hearts, offer solutions for advanced heart failure. New total artificial heart technologies aim to provide off-the-shelf options for biventricular or univentricular heart failure patients.

Keywords:
(Biventricular) heart failureBiventricular supportCardiogenic shockTotal artificial heart

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Last Updated: May 26, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
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Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Implantation of the Syncardia Total Artificial Heart
16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

Implantation of Total Artificial Heart in Congenital Heart Disease
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Published on: July 18, 2014

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Medicine
  • Medical Devices

Background:

  • Mechanical blood pumps were conceptualized in the 1950s to support failing hearts.
  • Left ventricular assist devices have significantly advanced heart failure treatment.
  • Current devices inadequately serve patients needing biventricular or univentricular support.

Purpose of the Study:

  • To review patient populations suitable for total artificial hearts (TAHs).
  • To discuss the management strategies for TAH recipients.
  • To examine emerging TAH technologies for unmet clinical needs.

Main Methods:

  • Literature review of mechanical circulatory support devices.
  • Analysis of patient cohorts for TAH candidacy.
  • Overview of current and developmental TAH technologies.

Main Results:

  • Left ventricular assist devices are established, but TAHs address broader heart failure.
  • New TAH generations are under development for comprehensive heart support.
  • Specific patient groups benefit from TAHs over left-sided devices.

Conclusions:

  • Total artificial hearts represent the next frontier in mechanical circulatory support.
  • Advancements in TAH technology promise improved outcomes for complex heart failure.
  • TAHs aim to become an off-the-shelf solution for biventricular and univentricular failure.