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Dolichocolon May Differentially Associate with Ulcerative Colitis Phenotype in Children.
Richard Kellermayer1,2,3, Donovan P Berens4, Réka G Szigeti5
1Division of Pediatric Gastroenterology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. kellerma@bcm.edu.
Dolichocolon (DC), an anatomical variant, may be linked to ulcerative colitis (UC) phenotypes, potentially influencing disease distribution irrespective of constipation. Further research is needed to confirm these findings.
Area of Science:
- Gastroenterology
- Pediatric Gastroenterology
- Radiology
Background:
- Dolichocolon (DC) is an underrecognized anatomical variant.
- The association between dolichocolon and ulcerative colitis (UC) remains unknown.
Purpose of the Study:
- To investigate the association between dolichocolon and ulcerative colitis (UC) in children.
- To explore potential links between DC subtypes and UC phenotypes.
Main Methods:
- Retrospective review of abdominal MRI and CT scans in children.
- Classification of DC subtypes in patients with UC, Crohn's disease (CD), and non-IBD controls.
- Analysis of DC prevalence in constipated and non-constipated UC patients.
Main Results:
- Dolichocolon was common in UC patients, regardless of constipation status.
- DC prevalence was higher in non-constipated UC patients compared to CD patients and controls.
- Specific DC subtypes (Type 1 and Type 2) were associated with distinct UC disease distributions (proctitis/left-sided vs. extensive/pancolitis).
Conclusions:
- Dolichocolon may be associated with varying UC phenotypes and influence disease extent independently of constipation.
- These findings require cautious interpretation due to the study's cross-sectional design.
- Longitudinal studies are necessary to confirm the observed associations.
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