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Anterior commissure involvement in Marchiafava-Bignami disease: MRI findings

Ying Chen1, Yin Lu2, Jie Chen3

  • 1Department of Neurology, The First People's Hospital of Guiyang, No. 97 Bo'ai Road, Nanming District, Guiyang City, Guizhou Province, China. 532523783@qq.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|May 25, 2026
PubMed

Insights

Marchiafava-Bignami disease, a rare condition linked to chronic alcohol abuse, can cause seizures and cognitive decline. Brain MRI reveals characteristic changes in the corpus callosum, indicating a toxic-metabolic demyelinating process.

Area of Science:

  • Neurology
  • Radiology
  • Toxicology

Background:

  • Chronic alcohol abuse is a significant public health concern with diverse neurological complications.
  • Marchiafava-Bignami disease (MBD) is a rare but severe neurological disorder associated with malnutrition and alcoholism.
  • Early recognition of MBD is crucial for timely intervention and potentially improving patient outcomes.
Keywords:
Anterior commissureChronic alcohol abuseCorpus callosumDiffusion-weighted imagingMarchiafava–Bignami disease

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