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Treatable traits in paediatric bronchiectasis: current practice and a proposed checklist
Joséphine Annereau1,2, Apolline Gonsard1,3, Rola Abou Taam1
1Department of Paediatric Pulmonology and Allergology, AP-HP, University Hospital Necker-Enfants Malades, 149, rue de Sèvres, F-75015, Paris, France.
European Journal of Pediatrics
|May 25, 2026
Summary
In children with non-cystic fibrosis bronchiectasis (NCFB), clinical assessments missed half of treatable traits (TTs), especially behavioral factors. A new checklist aims to improve structured assessment in routine care for NCFB patients.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
Background:
- Pediatric non-cystic fibrosis bronchiectasis (NCFB) management is individualized due to disease heterogeneity.
- A treatable traits (TT) approach offers precision medicine beyond standard guidelines.
Purpose of the Study:
- To evaluate the routine documentation of treatable traits (TTs) in children with NCFB.
- To identify gaps in the assessment of TTs in clinical practice.
- To propose a checklist for structured TT assessment in NCFB.
Main Methods:
- Retrospective study of children (<18 years) with CT-confirmed NCFB at a tertiary center (2010-2024).
- Assessed documentation of 41 predefined TTs across aetiological, pulmonary, extrapulmonary, and behavioural/environmental domains.
- Determined which TTs were assessed and identified per patient.
Main Results:
- Only 49% of 41 TTs were documented as assessed per patient among 121 children.
- Aetiological and pulmonary traits were more frequently assessed than extrapulmonary and behavioural traits.
- Psychosocial factors (anxiety, depression) and viral prevention were never documented; treatment adherence was rarely recorded.
Conclusions:
- Half of TTs were not routinely assessed in pediatric NCFB care, particularly psychosocial and behavioral aspects.
- A pragmatic TT checklist is proposed to guide structured, traceable assessment in routine NCFB care.
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