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Updated: May 26, 2026
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Gut microbiota-modulating interventions in paediatric type 1 diabetes: a systematic review and meta-analysis
Inmaculada Llopis-Alonso1, Melania Correa-Bares1, María Teresa Mercader-Ros1
1Faculty of Pharmacy and Nutrition, UCAM Universidad Católica San Antonio de Murcia, 30107, Murcia, Spain.
European Journal of Pediatrics
|May 25, 2026
Summary
Gut microbiota interventions may improve glycemic control in children with type 1 diabetes, reducing HbA1c and fasting glucose. However, more research is needed to confirm efficacy and optimal use.
Area of Science:
- Pediatric Endocrinology
- Microbiome Research
- Metabolic Disease Management
Background:
- Gut microbiota modulation is a potential adjunctive therapy for pediatric type 1 diabetes.
- Previous reviews had limited data and inconsistent findings on glycemic control.
Purpose of the Study:
- To systematically review and meta-analyze the efficacy and safety of gut microbiota-modulating interventions in children and adolescents with type 1 diabetes.
- To synthesize immune-inflammatory, microbiota-related, and intestinal permeability outcomes.
Main Methods:
- Systematic review and meta-analysis (PRISMA 2020) of randomized controlled trials.
- Searched major databases (PubMed, Scopus, Web of Science, CENTRAL) up to February 2026.
- Included 12 trials with 808 participants (≤19 years) using probiotics, prebiotics, or synbiotics.
Main Results:
- Significant reductions in glycated hemoglobin (HbA1c) and fasting blood glucose observed.
- No significant effects on total daily insulin dose or C-peptide levels.
- Immune-inflammatory, microbiota, and intestinal permeability outcomes suggested potential benefits but were inconsistently reported.
Conclusions:
- Gut microbiota interventions show promise for improving glycemic control (HbA1c, fasting glucose) in pediatric type 1 diabetes.
- Current evidence is limited by heterogeneity, insufficient to recommend specific formulations, doses, or durations.
- Larger, well-designed pediatric trials are necessary to confirm these findings and guide clinical practice.
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