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Updated: May 27, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Is it possible to differentiate benign/malignant unilateral sinonasal diseases from clinical and radiological
Zülküf Küçüktağ1, Bülent Öcal1, Cem Saka1
1Department of Otolaryngology Head and Neck Surgery, Etlik City Hospital, Ankara, Turkiye.
Objective:
The aim of this study is to determine the relationships between demographic, clinical, and radiological characteristics of patients with unilateral sinonasal diseases and the type of pathology, and to present a new algorithm that can help clinicians in the management of these patients.
Method:
The study included 243 patients who underwent surgery because of unilateral sinonasal diseases between 2014 and 2022. Patients were first divided into inflammatory and neoplastic groups and the neoplastic group was divided into benign and malignant groups.
Results:
Epistaxis and orbital complaints were seen significantly more in the neoplastic group, and anosmia/hyposmia in the inflammatory group. Epistaxis, orbital complaints, and pain were seen significantly more in the malignant group than in the benign group. On computed tomography scan, bone erosion and invasion of adjacent structures were seen significantly more in the neoplastic group and the malignant group.
Conclusions:
We present a new algorithm based on our clinical experience that can be used in the clinical management of unilateral sinonasal diseases.

