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Updated: May 27, 2026

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
Published on: December 2, 2022
Antifungal meroterpenoids from deep-sea-derived fungus Acremonium sclerotigenum
Ruiyun Huo1, Yitong Wang2, Guangrong Zi2
1State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Abstract:
Seven previously undescribed compounds, acrenoids A-G (1-7), along with two known compounds (8 and 9), were isolated from the culture of the deep-sea-derived fungus Acremonium sclerotigenum LW14. The structures of these compounds were characterized by a combination of spectroscopic studies, ECD calculations, and ECD experiments induced by Rh2(OCOCF3)4. Acrenoid A (1) features a distinctive 5/5/7 tricyclic ring framework. Moreover, all isolates were evaluated for their antifungal activities. Notably, compound 9 exhibited potent antifungal activity against drug-resistant Candida auris 12766, with a MIC of 4 μg/mL. In addition, compound 9 exhibited low hemolytic toxicity. The antifungal mechanism of compound 9 involves cell membrane disruption and intracellular ROS accumulation. In addition to these effects, it also inhibited biofilm formation in C. auris 12766. These findings highlight compound 9 as a promising antifungal candidate for treating C. auris.
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