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Related Concept Videos

Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.

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Related Experiment Video

Updated: May 27, 2026

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets
07:59

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Published on: October 15, 2021

Cardiac Labeling of Phase-Change Nanodroplets Enables Contrast-Controllable Super-Resolution Ultrasound.

Jinyu Yang1, Jiabin Zhang2, Feihong Dong3

  • 1School of Mechanics and Engineering Science, Peking University, Beijing, China.

Ultrasound in Medicine & Biology
|May 25, 2026
PubMed
Summary

Phase-change nanodroplets (PCNDs) enable precise microbubble concentration control for super-resolution ultrasound (SRUS) imaging. This novel approach offers improved image quality and opens new possibilities for cardiac and organ imaging.

Keywords:
Cardiac-labeling ultrasoundControllable microbubble concentrationSuper-resolution ultrasound imaging

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Acoustics

Background:

  • Microbubble concentration is critical for super-resolution ultrasound (SRUS) imaging quality.
  • Current contrast-enhanced ultrasound methods have limited control over microbubble concentration.
  • Phase-change nanodroplets (PCNDs) offer spatial and temporal control via acoustic activation.

Purpose of the Study:

  • To investigate the use of PCNDs for regulating microbubble concentration in SRUS imaging.
  • To evaluate the performance of PCNDs in achieving controlled microbubble generation for enhanced imaging.

Main Methods:

  • A cardiac-labeling SRUS strategy using two transducers (18 MHz) was developed.
  • PCNDs were activated using a custom pulse sequence with Trans #1.
  • Ultrafast plane wave imaging (600 Hz) was performed with Trans #2 for SRUS.

Main Results:

  • PCNDs were successfully activated in vivo in a mouse left ventricle.
  • Coordinated dual-transducer operation enabled SRUS imaging.
  • Microbubble concentration was effectively controlled by adjusting activation voltage (30-40V).

Conclusions:

  • The PCND-based SRUS strategy is feasible and repeatable in a mouse model.
  • This method provides a basis for high-quality, rapid SRUS imaging.
  • Dual-transducer activation of PCNDs allows precise control for advanced ultrasound applications.