Related Experiment Video
Updated: May 27, 2026
08:49
Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
Published on: August 2, 2024
Acute myocardial mechanical responses to colloid and crystalloid volume loading: A randomized double-blind crossover
Nidhal Bouchahda1, Fabian Scheipl2, Haithem Hbid1
1Cardiology A Department, Fattouma Bourguiba University Hospital, Monastir University, Monastir, Tunisia.
British Journal of Clinical Pharmacology
|May 25, 2026
Summary
Colloids like Gelafundin show distinct myocardial mechanical responses compared to crystalloids (0.9% sodium chloride) during volume resuscitation. These differences, particularly in left atrial strain, suggest fluid-modulated cardiac deformation patterns.
Area of Science:
- Cardiology
- Critical Care Medicine
- Fluid Resuscitation
Background:
- The superiority of colloids over crystalloids for volume resuscitation is debated.
- Distinct myocardial mechanical responses may explain differences in fluid efficacy.
Purpose of the Study:
- To investigate myocardial mechanical responses to colloid (Gelafundin 4%) versus crystalloid (0.9% sodium chloride) infusions.
- To compare left ventricular global longitudinal strain (GLS), torsion (TOR), left atrial strain (LAS), and right ventricular (RV) strain.
Main Methods:
- Single-centre, double-blind, randomized crossover trial.
- Sequential infusions of 500- and 1000-mL colloid or crystalloid in 20 healthy volunteers.
- Speckle-tracking echocardiography to assess GLS, TOR, LAS, and RV strain.
Main Results:
- Colloids favored GLS and RV strain compared to crystalloids.
- Left ventricular torsion increased significantly with colloid infusion.
- Left atrial strain showed the largest between-group differences, indicating distinct fluid-modulated adaptations.
Conclusions:
- Volume loading with colloids and crystalloids elicits distinct myocardial deformation patterns.
- Colloids may favor GLS and RV strain, while twist mechanics and left atrial function show fluid-modulated responses.
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