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Magnetic Resonance Imaging

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Visualizing pain-processing networks with 7T resting-state functional MRI using pseudo-continuous arterial spin

Andreas Nowacki¹, Sarah Waber², Jan Rosner^3,4,5

¹Department of Neurosurgery, Inselspital, University Hospital Bern, Bern, Switzerland. andreas.nowacki@insel.ch.

Scientific Reports

|May 25, 2026

Summary

This summary is machine-generated.

Ultra-high field 7T MRI with pseudo-continuous arterial spin labeling (pCASL) reveals brain perfusion changes during sustained pain. Regional cerebral blood flow (CBF) increases in pain-processing networks, closely correlating with perceived pain intensity.

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Area of Science:

Neuroimaging
Pain Research
Magnetic Resonance Imaging

Background:

Ultra-high field (7T) MRI offers superior signal-to-noise ratio and spatial resolution for functional imaging.
Arterial spin labeling (ASL) provides quantitative measurement of tissue perfusion.
Understanding brain perfusion changes during sustained pain is crucial for chronic pain research.

Purpose of the Study:

To investigate regional cerebral blood flow (CBF) changes during capsaicin-induced tonic pain using 7T ASL.
To explore the relationship between CBF alterations and perceived pain intensity.
To differentiate perfusion patterns between pain responders and weak responders.

Main Methods:

Twenty-seven healthy volunteers underwent 7T MRI including 3D turbo-FLASH pseudo-continuous ASL (pCASL) at baseline and during capsaicin-induced pain.
Participants rated pain intensity; cerebral blood flow (CBF) was calculated and analyzed in gray matter and predefined pain-matrix regions.
Voxel-wise regression and group comparisons were performed to correlate CBF with pain ratings and identify responder differences.

Main Results:

Global gray matter CBF remained unchanged, but regional CBF significantly increased (8-15%) in a distributed cortico-subcortical network, including insula, somatosensory cortices, ACC, and thalamus.
These regional CBF increases strongly correlated with perceived pain intensity (r≈0.66, p<0.001).
Weak responders exhibited distinct CBF patterns in visual and frontal regions compared to responders.

Conclusions:

7T pCASL enables quantitative mapping of brain perfusion during sustained pain.
Tonic nociception engages a broad network, with perfusion changes dynamically tracking pain intensity.
These findings highlight the potential of ultra-high field ASL in elucidating chronic pain mechanisms.