Related Experiment Video
Updated: May 27, 2026
06:34
In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
Published on: September 2, 2016
InNMR: Direct In Situ Studies of Transport Phenomena Enabled by an Innovative NMR-Tube Insert.
Amelie Frison1, Marit M Sørensen1, Kristoffer Prince1
1Department of Pharmacy, UiT the Arctic University of Norway, Box 6050, Langnes, 9037 Tromsø, Norway.
Analytical Chemistry
|May 25, 2026
Summary
Researchers developed a novel NMR tube insert enabling real-time transport studies. This technology facilitates advanced experiments in various scientific fields, including drug discovery and biochemistry.
Area of Science:
- Analytical Chemistry
- Biochemistry
- Chemical Biology
Background:
- Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for molecular analysis.
- Studying transport phenomena in real-time within NMR experiments presents challenges.
- Existing methods may lack the versatility to investigate complex diffusion-controlled processes.
Purpose of the Study:
- To introduce a novel discoid insert for standard NMR tubes.
- To enable the division of the NMR detection volume into multiple chambers using semipermeable barriers.
- To facilitate real-time studies of transport phenomena via NMR spectroscopy.
Main Methods:
- Development of a discoid insert and a plunger tool for easy positioning in NMR tubes.
- Attachment of various semipermeable barriers to the insert.
- Application of slice-selective NMR experiments to monitor transport processes.
- Demonstration through permeability studies, diffusion-controlled pH titrations, and diffusion-controlled protein titrations.
Main Results:
- Successful development and proof-of-concept for the novel NMR tube insert.
- Demonstrated ability to divide the NMR detection volume for controlled experiments.
- Validation of the approach in permeability, pH titration, and protein titration studies.
- Enabled real-time observation of diffusion-controlled processes.
Conclusions:
- The developed NMR tube insert offers a versatile platform for studying transport phenomena.
- This technology expands the capabilities of NMR spectroscopy for various scientific disciplines.
- Opens new avenues for research in drug discovery, biochemistry, and chemical biology.
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