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Prevalence, Severity, and Clinical Course of Atopic Dermatitis in Japan: A Web-Based Questionnaire Survey
Takeshi Nakahara1, Sakae Kaneko2, Norito Katoh3
1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
The Journal of Dermatology
|May 26, 2026
Summary
Atopic dermatitis (AD) prevalence peaks in childhood, declining with age but persisting into adulthood for many. Disease courses vary, with remission more common in females and persistence in males.
Area of Science:
- Dermatology
- Epidemiology
- Clinical Medicine
Background:
- Atopic dermatitis is a chronic inflammatory skin condition often starting in childhood.
- Its long-term clinical course is highly variable and not fully understood.
- Understanding age-specific patterns is crucial for effective management.
Purpose of the Study:
- To evaluate the age-specific prevalence, remission rates, severity, and disease course of atopic dermatitis in Japan.
- To identify differences in disease patterns based on age and sex.
- To provide insights into the lifelong trajectory of atopic dermatitis.
Main Methods:
- A cross-sectional questionnaire survey was conducted among dermatologists in Japan.
- Data from 7,777 individuals (respondents and family members) were analyzed.
- Analysis focused on prevalence, remission proportion, severity, and disease course stratified by age and sex.
Main Results:
- Atopic dermatitis prevalence peaked between 5-9 years, declining with age but remaining significant in adults.
- Remission proportion increased with age, plateauing around 40 years, and was higher in females.
- Childhood-onset remission was the most common course, followed by relapse, persistence, and adult-onset; males showed more persistent/relapsing patterns.
Conclusions:
- Atopic dermatitis affects a substantial number of adults, with diverse lifelong clinical trajectories.
- Significant differences in disease course and remission exist between sexes.
- Further research into sex-specific management strategies for atopic dermatitis is warranted.
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