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Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
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Published on: February 9, 2024

The silent epidemic: Cardiovascular mortality among patients with thyroid disorders-Insights from CDC-WONDER database

Maryam Saghir1, F N U Kritika2, Mirza Mohammad Ali Baig3

  • 1Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|May 26, 2026
PubMed

Insights

Mortality from cardiovascular diseases (CVDs) and thyroid disorders combined is rising in US adults. This trend underscores the urgent need for better monitoring and prevention strategies for these interconnected conditions.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Public Health Epidemiology

Background:

  • Thyroid disorders are significant contributors to cardiovascular diseases (CVDs) in the U.S.
  • Existing data lacks specific trends on CVD-related mortality in patients with thyroid disorders.
  • Understanding these combined impacts is crucial for public health initiatives.

Purpose of the Study:

  • To analyze trends in CVD-related mortality among adults with coexisting thyroid disorders in the U.S. from 1999 to 2023.
  • To identify demographic and geographic patterns associated with this mortality.
  • To inform targeted public health interventions.

Main Methods:

  • Retrospective analysis of the CDC Wide-Ranging Online Data for Epidemiologic Research (WONDER) database.
  • Inclusion of adult deaths (≥25 years) with recorded CVD and thyroid disorders from 1999-2023.
  • Calculation of age-adjusted mortality rates (AAMRs) and annual percent change (APC), stratified by demographics and region.

Main Results:

  • Over 513,000 deaths were recorded due to combined CVD and thyroid disorders.
  • Ischemic heart disease was the leading cause (59.43%).
  • Overall AAMR increased from 8.63 in 1999 to 10.82 in 2023 (APC 0.76).
  • Higher AAMRs were observed in women, non-Hispanic White individuals, the Midwest region, and nonmetropolitan areas.
  • Wyoming, Nebraska, Oklahoma, South Dakota, and West Virginia showed the highest mortality rates.

Conclusions:

  • A significant rise in mortality among U.S. adults with coexisting CVD and thyroid disorders was observed between 1999 and 2023.
  • The increasing trend highlights the critical need for enhanced surveillance and proactive prevention strategies.
  • Integrated approaches to managing these interconnected conditions are essential.

Keywords:
cardiovascular diseasesdeathendocrinologythyroid diseases

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