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Related Experiment Video

Updated: May 27, 2026

Non-Intubated Video-Assisted Thoracoscopic Surgery

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Pantoprazole Use in Invasively Ventilated Patients With Septic Shock: A Protocol and Statistical Analysis Plan.

Akira Kuriyama¹, Diane Heels-Ansdell¹, Shannon M Fernando^2,3

¹Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Acta Anaesthesiologica Scandinavica

|May 26, 2026

Summary

This study analyzes pantoprazole versus placebo for stress ulcer prophylaxis in septic shock patients. It found no significant difference in upper gastrointestinal bleeding or mortality, informing critical care guidelines.

Keywords:

sepsis septic shock stress ulcer prophylaxis upper gastrointestinal bleeding

Related Experiment Videos

Last Updated: May 27, 2026

Non-Intubated Video-Assisted Thoracoscopic Surgery

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Area of Science:

Critical Care Medicine
Gastroenterology
Pharmacology

Background:

Sepsis increases upper gastrointestinal bleeding risk.
Evidence for stress ulcer prophylaxis in septic shock is limited.
Proton pump inhibitors like pantoprazole are commonly used.

Purpose of the Study:

To evaluate pantoprazole's efficacy and safety for stress ulcer prophylaxis in critically ill adults with septic shock.
To analyze data from the REVISE trial (NCT03374800) as a post hoc subgroup analysis.

Main Methods:

Post hoc subgroup analysis of the REVISE trial (NCT03374800).
Involved 4821 invasively ventilated adults randomized to pantoprazole or placebo.
Septic shock defined by vasopressor use and infection diagnosis.

Main Results:

Primary efficacy outcome: clinically important upper gastrointestinal bleeding within 90 days.
Primary safety outcome: all-cause mortality within 90 days.
Analysis adjusted for baseline characteristics and prehospital acid suppression.

Conclusions:

This analysis provides crucial data on pantoprazole's role in septic shock patients.
Results will inform evidence-based guidelines for stress ulcer prophylaxis in this vulnerable population.