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Cardioneuroablation for children with syncope.

Mitchell I Cohen¹, Jordan A Cohen²

¹Department of Pediatric Cardiology, Inova Children's Hospital and the University of Virginia School Medicine, Fairfax, Virginia.

Current Opinion in Cardiology

|May 26, 2026

Summary

This summary is machine-generated.

Cardioneuroablation offers a promising alternative for children with recurrent syncope who haven

Keywords:

autonomic ablation cardioneuroablation syncope vagal

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Area of Science:

Pediatric Cardiology
Electrophysiology
Autonomic Nervous System Regulation

Background:

Recurrent syncope in children can significantly impact quality of life.
Traditional therapies for cardioinhibitory syncope may not always be effective.
Pacemaker implantation is an option but carries its own risks and considerations.

Purpose of the Study:

To review the application and outcomes of cardioneuroablation in pediatric patients.
To evaluate cardioneuroablation as an alternative to pacemaker implantation for refractory syncope.
To assess the current evidence for cardioneuroablation in children with cardioinhibitory syncope.

Main Methods:

Review of existing literature on cardioneuroablation in pediatric populations.
Analysis of studies reporting on catheter ablation of ganglionated plexuses.
Examination of different technical approaches, including ablation in the right or left atrium.

Main Results:

Cardioneuroablation has a long history in adults with cardioinhibitory syncope, showing 85-90% success rates.
Limited but promising data suggests similar success in pediatric patients.
The long-term effects of disrupting sympathovagal imbalance require further investigation.

Conclusions:

Cardioneuroablation is a potential treatment for select pediatric patients with cardioinhibitory syncope unresponsive to medical therapy.
Early results indicate that vagal ablation in children is promising.
Long-term follow-up registries are necessary to fully understand the outcomes of pediatric cardioneuroablation.