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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Videos

Short-Term Intraocular Pressure Trends After Intravitreal Pegcetacoplan Injection.

Nathaniel P Goldblatt1, Anirudh Mukhopadhyay1, D Anthony Mazzulla2

  • 1Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Journal of Vitreoretinal Diseases
|May 26, 2026
PubMed
Summary

Intravitreal injections of pegcetacoplan for geographic atrophy can cause a high initial intraocular pressure (IOP) spike. However, most patients did not require intervention for acute IOP control.

Keywords:
complement inhibitorgeographic atrophyglaucomaintraocular pressureintravitreal injectionpegcetacoplan

Related Experiment Videos

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Pharmacology

Background:

  • Geographic atrophy (GA) is an advanced form of age-related macular degeneration.
  • Intravitreal injections (IVI) are a common treatment for retinal diseases.
  • Pegcetacoplan is an investigational drug for GA.

Purpose of the Study:

  • To assess the short-term intraocular pressure (IOP) response following intravitreal injections (IVI) of pegcetacoplan.
  • To evaluate the need for anterior chamber (AC) paracentesis for IOP management post-IVI.

Main Methods:

  • Retrospective, cross-sectional study of patients receiving pegcetacoplan IVI for GA.
  • Data collected included baseline IOP, post-injection IOP, and AC paracentesis.
  • Analysis of factors influencing IOP, including posterior vitreous detachment (PVD) and prior injection response.

Main Results:

  • Mean post-IVI IOP was 64 mm Hg; 63.4% of eyes exceeded 60 mm Hg.
  • Only 6.3% of eyes required AC paracentesis for acute IOP control.
  • Patients with PVD had significantly higher post-IVI IOP compared to those without (P=.01).
  • Previous injection IOP response predicted subsequent IOP spikes.

Conclusions:

  • Pegcetacoplan IVI for GA can lead to a significant, but generally transient, IOP spike.
  • AC paracentesis is rarely needed for acute IOP management.
  • PVD and prior severe IOP responses are associated with higher post-injection IOP.