Related Experiment Video
Updated: May 28, 2026
09:12
A Quantitative Fluorescence Microscopy-based Single Liposome Assay for Detecting the Compositional Inhomogeneity Between Individual Liposomes
Published on: December 13, 2019
Molecular investigation to quantify the translocation of siRNA-NAPA oligomer complexes through lipid membranes
Desh Deepak Yadav1, Debdip Bhandary2, Pradip Paik1
1School of Biomedical Engineering, Indian Institute of Technology (BHU), Varanasi, U. P. - 221005, India. paik.bme@iitbhu.ac.in.
Physical Chemistry Chemical Physics : PCCP
|May 26, 2026
Abstract:
Molecular dynamics and umbrella sampling were employed to investigate the translocation of siRNA-NAPA oligomer complexes across a POPC membrane, revealing a high energy barrier (63-95 kcal mol-1) accompanied by significant membrane deformation, underscoring the need for improved carrier design in siRNA therapeutics.
