Wearable Dual-Mode Biosensing System for Dynamic Light Dosimetry in Tissues

Area of Science:

• Biomedical Engineering
• Photomedicine
• Wearable Technology

Background:

• Phototherapy relies on precise light dosimetry for efficacy.
• Current devices lack real-time, personalized monitoring and tunable light sources.
• Existing systems often use bulky hardware and surface measurements, limiting accuracy.

Purpose of the Study:

• To develop a wearable, integrated dual-mode sensing system for dynamic tissue light dose monitoring.
• To enable real-time feedback on light dose distribution and temperature changes.
• To create a proof-of-concept for a more precise and personalized phototherapy approach.

Main Methods:

• A diffusion equation-based model was employed.
• A wearable system with a single-chip microcontroller and a custom multi-wavelength LED optical probe was designed.
• Integrated thermal sensing was used for synchronous temperature monitoring.

Main Results:

• The system demonstrated real-time dynamic monitoring of tissue optical parameters.
• It provided feedback on light dose distribution and estimated combined photothermal effects.
• The proof-of-concept showed compact design, user-friendliness, and reliable detection.

Conclusions:

• The developed wearable system offers a novel approach to dynamic phototherapy monitoring.
• It has the potential for personalized, safe, and effective home-use phototherapy.
• This technology could lead to more cost-effective and portable phototherapy solutions.