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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
What is the Immune System?01:38

What is the Immune System?

Overview

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Related Experiment Video

Updated: May 28, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

The Landscape of Genetically Driven Immune Disorders.

Xiao P Peng1, Jo L Wilson2, Dusan Bogunovic3,4

  • 1New York Center for Rare Diseases, Division of Pediatric Genetic Medicine, Department of Pediatrics, Montefiore Medical Center and Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.

NEJM Evidence
|May 26, 2026
PubMed
Summary

Genetic diagnostic testing reveals complex immune disorder patterns. This review aids clinicians in navigating diagnosis and management strategies for genetically driven immune disorders.

Related Experiment Videos

Last Updated: May 28, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

  • Immunology
  • Genetics
  • Clinical Medicine

Background:

  • Genetic diagnostic testing has advanced understanding of immune disorders.
  • Increased genetic data presents diagnostic and care complexities for clinicians.

Purpose of the Study:

  • To review concepts of genetically driven immune disorders.
  • To guide clinicians in current diagnostic and management strategies.

Main Methods:

  • Literature review of genetic diagnostic testing and immune disorders.
  • Synthesis of current diagnostic and management approaches.

Main Results:

  • Genetic insights into immune disorders are expanding.
  • Complexity in diagnosis and care requires updated strategies.

Conclusions:

  • Clinicians need clear frameworks to manage genetically driven immune disorders.
  • Navigating genetic complexities is crucial for effective patient care.