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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

Guidance for Canadian Breast Cancer Practice: National Consensus Recommendations for the Systemic Treatment of

Christine Simmons1, Omar F Khan2, Christine Brezden-Masley3

  • 1BC Cancer-Vancouver, University of British Columbia, Vancouver, BC V5Z 4E6, Canada.

Current Oncology (Toronto, Ont.)
|May 26, 2026
PubMed

Insights

New guidelines offer evidence-based recommendations for triple-negative breast cancer (TNBC) treatment in Canada. These consensus recommendations aim to improve consistent and effective care for TNBC patients across the country.

Area of Science:

  • Oncology
  • Clinical Practice Guidelines

Background:

  • Triple-negative breast cancer (TNBC) presents a poorer prognosis and more aggressive behavior compared to other breast cancer subtypes.
  • Recent therapeutic advancements since 2020 have improved TNBC outcomes, yet treatment implementation varies across Canada.

Purpose of the Study:

  • To develop national clinical consensus recommendations for the management of breast cancer, specifically focusing on triple-negative breast cancer.
  • To support the integration of new therapies into clinical practice and ensure consistent, evidence-informed care for TNBC patients.

Main Methods:

  • A pan-Canadian group, REAL Alliance, comprising breast cancer specialists and a patient advocacy organization, conducted a selective literature review.
  • A modified Delphi process involving national experts in medical oncology, radiation oncology, surgical oncology, and pharmacy was employed.

Main Results:

  • A comprehensive set of 23 national consensus recommendations for TNBC management was developed.
  • The recommendations include four general points, 11 for early-stage TNBC, and eight for metastatic TNBC.

Conclusions:

  • The developed recommendations provide evidence-informed guidance for oncology healthcare professionals in Canada.
  • The goal is to standardize and improve the consistency of care for patients with triple-negative breast cancer nationwide.
Keywords:
Canadian consensus recommendationsREAL AllianceTNBCbreast cancerevidence-informed

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