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Published on: April 17, 2012
Global Disparities and Trends in Radiotherapy for Early-Stage Glottic Cancer.
Issa Mohamad1, Shatha Abu Taha1, Ahmad Bushehri2
1Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan.
Current Oncology (Toronto, Ont.)
|May 26, 2026
Summary
Global radiotherapy practices for early-stage glottic cancer show significant variations. Standardized guidelines are needed to improve patient care and outcomes worldwide.
Area of Science:
- Oncology
- Radiation Oncology
- Head and Neck Cancer
Background:
- Early-stage glottic cancer (ESGC) management relies on radiotherapy.
- Global practices for ESGC radiotherapy are not well-standardized.
Purpose of the Study:
- To evaluate current global radiotherapy practices for early-stage glottic cancer.
- To identify variations in treatment modalities and identify areas for guideline development.
Main Methods:
- A global online survey of radiotherapy practices for ESGC was conducted in March 2025.
- Data collected included staging, target delineation, radiotherapy techniques, dose/fractionation, and image guidance.
- 181 responses were analyzed, with a focus on geographical and institutional differences.
Main Results:
- Intensity-Modulated Radiation Therapy (IMRT) was the most common planning technique (82.9%).
- Hypofractionated schedules predominated for T1 (84%) and T2 (72.4%) disease.
- Significant geographical variations were observed in vocal cord irradiation and accelerated fractionation for T2 disease.
Conclusions:
- Substantial global disparities exist in radiotherapy for ESGC, influenced by access and institutional protocols.
- Standardized, evidence-based global guidelines are crucial for harmonizing care and improving outcomes.
- Further research, including randomized trials, is supported by a majority of practitioners.
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