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Related Experiment Video

Updated: May 28, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

A Consensus Approach to the Incorporation of Total Neoadjuvant Therapy in a Treatment Algorithm for Stage I-III

Sami A Chadi1,2, Karineh Kazazian1,2, Paul Savage2

  • 1Sprott Department of Surgery, Division of General Surgery and Surgical Oncology, University Health Network and Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada.

Current Oncology (Toronto, Ont.)
|May 26, 2026
PubMed

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Impact of Frontline Systemic Treatment Choice on Clinical Outcome in Advanced Leiomyosarcoma: A CanSaRCC Study.

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Evaluation of Machine Learning and Statistical Models for Predicting Long Term Gastrostomy Tube Dependency in Patients Undergoing Major Oral Cavity Cancer Surgery With Free Flap Reconstruction.

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Correction: Transcriptomic profiling of a novel gastric implantation model identifies mechanisms and pathways that drive implantation into explanted human peritoneum.

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Auto-segmentation of organs-of-interest clinical acceptability & reproducibility framework in head and neck cancer.

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Salvage Radiotherapy in Isolated Locoregional Recurrence of Pancreatic Adenocarcinoma Post-Radical Surgical Resection: Prudent or Pointless? A Retrospective Comparative Analysis.

Current oncology (Toronto, Ont.)·2026
Summary

Total neoadjuvant therapy (TNT) improves outcomes for rectal cancer patients. This study develops an institutional algorithm for TNT in stage I-III rectal cancer, addressing treatment heterogeneity and aiming for organ preservation.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Rectal adenocarcinoma treatment has advanced with improved surgery, imaging, radiotherapy, and chemotherapy.
  • Evolving strategies include total neoadjuvant therapy (TNT) and organ preservation.
  • TNT involves administering all adjuvant therapy preoperatively for resectable, non-metastatic rectal cancer.

Purpose of the Study:

  • To develop a consensus-based institutional treatment algorithm for stage I-III rectal cancer.
  • To incorporate current evidence and address heterogeneity in TNT sequencing and management.
  • To guide ambulatory and multidisciplinary team settings for optimal rectal cancer treatment.

Main Methods:

  • Review and synthesis of current evidence on total neoadjuvant therapy (TNT).
Keywords:
consensusnon-operative managementrectal cancertotal neoadjuvant therapytreatment algorithm

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  • Development of a consensus-based institutional treatment algorithm.
  • Focus on stage I-III rectal cancer, including mismatch repair proficient cases.

    • Main Results:

    • Established an institutional treatment algorithm for stage I-III rectal cancer.
    • Addressed heterogeneity in TNT sequencing, dosing, and non-operative management.
    • Facilitated maximizing tumor response, improving compliance, and enabling organ preservation.

    Conclusions:

    • The developed algorithm provides a framework for implementing TNT in rectal cancer care.
    • It aims to optimize treatment outcomes, including organ preservation and survival.
    • Standardizing TNT protocols is crucial for managing rectal adenocarcinoma effectively.