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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Videos

Cancer During Pregnancy: Navigating Clinical and Research Challenges.

Mackenzie K Callaway1, Lizelle Comfort2, Dhivyaa Anandan1,3

  • 1Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Current Oncology (Toronto, Ont.)
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

Cancer during pregnancy is increasing, but knowledge and treatment are limited. This review identifies key challenges and proposes strategies for better diagnosis, treatment, and outcomes for both mother and child.

Keywords:
cancercancer during pregnancyhealth disparitymaternal–fetal care

Related Experiment Videos

Area of Science:

  • Oncology
  • Maternal-Fetal Medicine
  • Reproductive Health

Background:

  • Rising incidence of cancer during pregnancy presents significant clinical and research challenges.
  • Underdeveloped scientific understanding and clinical management strategies hinder effective treatment.
  • Limited model systems and mechanistic studies impede biological insights into gestational cancers.

Purpose of the Study:

  • To evaluate the current state of pregnancy-associated cancers.
  • To identify unmet clinical and biological questions in the field.
  • To propose strategies for improving diagnosis, treatment, and maternal-fetal outcomes.

Main Methods:

  • Multidisciplinary expert review and synthesis of existing literature.
  • Evaluation of current diagnostic and therapeutic approaches.
  • Identification of knowledge gaps and research priorities.

Main Results:

  • Delayed diagnoses and limited therapeutic options are significant clinical hurdles.
  • Lack of safety data for treatments during pregnancy complicates management.
  • Poor understanding of gestational cancer biology requires further investigation.

Conclusions:

  • There is an urgent need for improved strategies to address the complexities of cancer in pregnancy.
  • Further research into gestational cancer biology and clinical management is essential.
  • Enhanced multidisciplinary collaboration is crucial for improving maternal-fetal outcomes.