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Updated: May 28, 2026
09:31
Calcium Carbonate Formation in the Presence of Biopolymeric Additives
Published on: May 14, 2019
Wnt/β-Catenin Pathway and Hydraulic Calcium Silicate-Based Cements: A Narrative Review
Carmela Del Giudice1, Carmen Vito1, Gianrico Spagnuolo1
1Department of Neuroscience, Reproductive Science and Dentistry, Federico II University of Naples, 80131 Naples, Italy.
Dentistry Journal
|May 26, 2026
Summary
Hydraulic calcium silicate-based cements (HCSBCs) may enhance Wnt/β-catenin signaling, promoting dental stem cell activation and reparative dentinogenesis. This understanding could lead to advanced biomaterials for dental pulp regeneration.
Area of Science:
- Biomaterials Science
- Cell Biology
- Regenerative Dentistry
Background:
- The Wnt/β-catenin signaling pathway is crucial for cellular processes and tooth development.
- This pathway is vital for reparative and regenerative mechanisms in mineralized tissues like dentin.
- Hydraulic calcium silicate-based cements (HCSBCs) are bioactive materials used in endodontics.
Purpose of the Study:
- To review the role of Wnt signaling in oral tissues.
- To explore the interaction between HCSBCs and Wnt signaling.
- To hypothesize how HCSBCs modulate Wnt signaling for dental repair.
Main Methods:
- Narrative review of existing literature.
- Analysis of Wnt signaling pathways in oral tissues.
- Investigation of HCSBCs' biological effects on dental stem cells.
Main Results:
- HCSBCs show potential in promoting odontogenic responses and reparative dentinogenesis.
- These effects are possibly mediated by the modulation of the Wnt/β-catenin signaling pathway.
- HCSBCs may activate dental stem cells through released products and mediators.
Conclusions:
- Wnt signaling plays a key role in the dentin-pulp complex's response to HCSBCs.
- HCSBCs might enhance Wnt pathway activation, supporting regenerative processes.
- Further understanding can guide the development of next-generation biomaterials for dental regeneration.
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