DAGs and GRaSP Causal Inference Algorithms Combined and Applied to the Calculation of Insulin Bolus in Patients with...

Type 1 diabetes mellitus (T1DM) is a chronic, non-preventable, and incurable disease that requires lifelong insulin administration. The principal challenge is calculating the prandial insulin bolus to avoid hypoglycemia and hyperglycemia. Traditional bolus calculators are based on limited number of variables, but there are many variables that define the complex interactions among glucose levels, like carbohydrate intake, physical activity, mood, and contextual factors. While recent artificial intelligence (AI) approaches have shown promise in glucose prediction, most remain correlational and offer limited interpretability for clinical decision support. This study evaluates a causal inference-based framework for insulin bolus calculation using Directed Acyclic Graphs (DAGs) and the Greedy Relaxation of the Sparsest Permutation (GRaSP). Historical data from individuals with T1DM were analyzed, incorporating domain knowledge constraints to guide structure learning. A bootstrap-based stability analysis was conducted to evaluate the robustness of inferred relationships. Results show that integrating prior medical knowledge reduces graph complexity and improves interpretability. However, bootstrap stability reflects robustness of the learning procedure rather than causal validity. The findings suggest that the proposed framework is useful for generating plausible causal hypotheses, but not for confirming causal relationships. Further validation using conditional independence testing, equivalence class analysis, and temporal causal methods is required. However, the proposed framework focuses on generating plausible causal hypotheses rather than establishing causal validity, which requires further refutation-based validation.