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Related Concept Videos

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Related Experiment Video

Updated: May 28, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

Circulating Lipid Traits and Ovarian Cancer Risk: A Systematic Review and Meta-Analysis with Mendelian Randomization

Marco Marian1,2, Andrei Ardelean3, Mihai Rosu3

  • 1Doctoral School, Victor Babes University of Medicine and Pharmacy, E. Murgu Square, No. 2, 300041 Timisoara, Romania.

Metabolites
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

Elevated triglycerides (TG) may increase ovarian cancer risk, while high-density lipoprotein cholesterol (HDL-C) shows a modest protective effect. This systematic review suggests TG could be a key metabolic risk factor for ovarian cancer.

Keywords:
HDL cholesterolMendelian randomizationcancer epidemiologylipid metabolismmeta-analysismetabolic risk factorsovarian cancertriglycerides

Related Experiment Videos

Last Updated: May 28, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
13:04

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose

Published on: October 14, 2015

Area of Science:

  • Oncology
  • Metabolic Research
  • Epidemiology

Background:

  • Metabolic dysregulation is a known factor in cancer development.
  • The specific role of lipid profiles in ovarian cancer risk is not well-established.
  • Ovarian cancer remains a significant global health concern.

Purpose of the Study:

  • To systematically review and meta-analyze the association between circulating lipid traits and ovarian cancer risk.
  • To investigate the potential causal relationship between lipids and ovarian cancer using Mendelian randomization.
  • To clarify the role of triglycerides, HDL-C, LDL-C, and total cholesterol in ovarian cancer etiology.

Main Methods:

  • Systematic review and meta-analysis adhering to PRISMA 2020 guidelines.
  • Searched major databases (PubMed, Web of Science, Scopus, Embase) for observational studies.
  • Employed random-effects models for pooling relative risks and Mendelian randomization for causal inference.

Main Results:

  • Meta-analysis of six studies revealed elevated triglycerides are associated with increased ovarian cancer risk.
  • High-density lipoprotein cholesterol (HDL-C) demonstrated a modest inverse association with risk.
  • Low-density lipoprotein cholesterol (LDL-C) and total cholesterol showed no significant association; Mendelian randomization supported a causal role for triglycerides.

Conclusions:

  • Circulating triglycerides may be a metabolically relevant risk factor for ovarian cancer.
  • Further large-scale prospective and mechanistic studies are needed to confirm these findings.
  • Lipid profiles, particularly triglycerides, warrant further investigation in ovarian cancer research.