Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The endoplasmic reticulum is a target organelle for trivalent dimethylarsinic acid (DMAIII)-induced cytotoxicity.

Toxicology and applied pharmacology·2012
Same author

(E)-1-{4-[Bis(4-bromo-phen-yl)meth-yl]piperazin-1-yl}-3-(4-eth-oxy-phen-yl)prop-2-en-1-one.

Acta crystallographica. Section E, Structure reports online·2012
Same author

(E)-1-{4-[Bis(4-bromo-phen-yl)meth-yl]piperazin-1-yl}-3-(4-methyl-phen-yl)prop-2-en-1-one.

Acta crystallographica. Section E, Structure reports online·2012
Same author

(E)-3-(1,3-Benzodioxol-5-yl)-1-{4-[bis-(4-meth-oxy-phen-yl)meth-yl]piperazin-1-yl}prop-2-en-1-one.

Acta crystallographica. Section E, Structure reports online·2012
Same author

Economic evaluation of first-line treatments for metastatic renal cell carcinoma: a cost-effectiveness analysis in a health resource-limited setting.

PloS one·2012
Same author

Metabolism studies of casticin in rats using HPLC-ESI-MS(n).

Biomedical chromatography : BMC·2012
Same journal

Lactate Metabolism Dysregulation Drives the Pathogenesis of Acute Kidney Injury.

Metabolites·2026
Same journal

Librarian: An Open-Access Web Application for High-Resolution Mass Spectral Library Assembly.

Metabolites·2026
Same journal

Purine Metabolism Alterations in Patients with Chronic Heart Failure: A Cross-Sectional Study of Associations with Iron Status, Oxidative Stress, and Anemia.

Metabolites·2026
Same journal

The Gut Microbiome in Heart Failure: Pathways to Inflammation and Therapeutic Targets.

Metabolites·2026
Same journal

Metabolic Mechanisms of Hexavalent Chromium-Induced Splenic Immune Injury via Oxidative Stress and Ferroptosis Pathways in New Zealand Rabbits.

Metabolites·2026
Same journal

Improving Speed and Efficiency of DESI Imaging with the Xevo MRT Mass Spectrometer for Analyte Mapping.

Metabolites·2026
See all related articles

Related Experiment Video

Updated: May 28, 2026

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
11:43

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

Spatially Resolved Metabolomic Profiling Reveals Progression-Associated Metabolic Reprogramming in Colorectal Liver

Ying Zhu1, Yixuan Cai1, Qianyu Wang2

  • 1Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Metabolites
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

Colorectal cancer liver metastasis (CRLM) shows distinct metabolic profiles. Lipid and amino acid metabolism changes are key features, offering potential biomarkers for detecting liver metastasis in colorectal cancer patients.

Keywords:
colorectal cancerliver metastasismass spectrometry imagingmetabolic landscapespatially resolved metabolomics

More Related Videos

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

Related Experiment Videos

Last Updated: May 28, 2026

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
11:43

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

Area of Science:

  • Oncology
  • Metabolomics
  • Cancer Biology

Background:

  • Colorectal cancer (CRC) is a major cause of cancer mortality, with liver metastasis (CRLM) significantly worsening prognosis.
  • Tumor metabolic reprogramming and spatial heterogeneity present challenges in biomarker discovery and clinical management for CRC.
  • Understanding metabolic alterations is crucial for identifying effective therapeutic targets and diagnostic markers.

Purpose of the Study:

  • To spatially characterize the metabolomic landscape of colorectal cancer (CRC).
  • To identify metabolic alterations associated with CRC progression and liver metastasis.
  • To discover potential metabolic signatures for diagnosing colorectal liver metastasis (CRLM).

Main Methods:

  • Utilized air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) on 23 CRC tissue samples.
  • Performed region-of-interest analysis guided by histopathology for comparative metabolomic profiling.
  • Employed multivariate statistics, pathway enrichment, and ROC curve analyses for biomarker evaluation.

Main Results:

  • Distinct spatial metabolomic profiles were observed across normal mucosa, primary tumors, liver metastases, and normal liver.
  • Primary CRC tumors showed upregulated amino acid, purine, and choline metabolism.
  • Liver metastases exhibited elevated lipids (triglycerides, diglycerides, cholesteryl esters) and acylcarnitines, suggesting altered lipid metabolism and mitochondrial function.
  • A panel of four lipids demonstrated strong discriminatory performance between metastatic and non-metastatic CRC.

Conclusions:

  • This study provides a spatially resolved map of metabolic reprogramming in CRC progression and liver metastasis.
  • Lipid and amino acid metabolism are identified as key metabolic pathways involved in CRLM.
  • The identified metabolic signatures offer potential diagnostic biomarkers for colorectal liver metastasis.