Association of the C-Reactive Protein-Triglyceride-Glucose Index with Stroke-Heart Syndrome and Clinical Prognosis in

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Wenjie Chen1, Xuesong Bai2, Tao Wang2

  • 1Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.

Journal of Cardiovascular Development and Disease
|May 26, 2026
PubMed

Insights

The C-reactive protein-triglyceride-glucose index (CTI) predicts cardiac injury and poor outcomes in acute ischemic stroke (AIS) patients. This simple index helps identify high-risk individuals for stroke-heart syndrome after AIS.

Area of Science:

  • Cardiology
  • Neurology
  • Biomarkers

Background:

  • Stroke-heart syndrome (SHS), including acute myocardial injury, is a severe complication of acute ischemic stroke (AIS).
  • The C-reactive protein-triglyceride-glucose index (CTI) combines inflammatory and metabolic markers.
  • The predictive value of CTI for cardiac complications post-AIS is unknown.

Purpose of the Study:

  • To investigate if the CTI can predict cardiac injury patterns in AIS patients.
  • To determine if CTI predicts 90-day clinical outcomes, including functional status and mortality, in AIS patients.

Main Methods:

  • A retrospective cohort study of 493 AIS patients undergoing endovascular treatment (EVT) at two centers.
  • Cardiac troponin I (cTnI) trajectories were categorized into no injury, non-dynamic elevation, and dynamic elevation.
  • Primary endpoint: poor functional status (modified Rankin Scale [mRS] 3-6) at 90 days. Secondary endpoint: 90-day all-cause death.

Main Results:

  • Higher baseline CTI correlated with increased likelihood of dynamic troponin elevation (aOR=1.56).
  • Dynamic troponin elevation was linked to significantly worse outcomes compared to no injury.
  • Elevated CTI independently predicted poor 90-day functional outcome (Q4: aOR=3.04) and mortality (Q4: aOR=2.82).

Conclusions:

  • The CTI serves as a predictor of stroke-heart syndrome (SHS) in AIS patients treated with EVT.
  • The CTI is associated with adverse 90-day clinical outcomes.
  • This easily calculated CTI index can aid in identifying AIS patients at higher risk for cardiac complications.
Abstract

Keywords:
C-reactive protein–triglyceride–glucose indexacute ischemic strokeendovascular thrombectomystroke–heart syndrome

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