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Published on: August 28, 2018

The Correlation Between Plasma CACNA2D1 Protein Concentration and the Severity of Coronary Heart Disease

Le An1, Yanhui Ren1,2, Jin Yang3

  • 1Department of Cardiology, Central Hospital of Dalian University of Technology, Dalian 116033, China.

Journal of Cardiovascular Development and Disease
|May 26, 2026
PubMed

Insights

Plasma CACNA2D1 protein concentration correlates with coronary artery stenosis severity. This finding suggests CACNA2D1 may serve as a novel biomarker for early coronary heart disease detection.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Protein Analysis

Background:

  • Coronary heart disease (CHD) prevalence is increasing globally.
  • Early detection methods for CHD are currently limited.
  • Identifying novel biomarkers is crucial for timely diagnosis and intervention.

Purpose of the Study:

  • To investigate the correlation between plasma CACNA2D1 protein concentration and the severity of coronary artery stenosis.
  • To explore the potential of CACNA2D1 as a biomarker for coronary heart disease.

Main Methods:

  • 267 inpatients undergoing coronary angiography were enrolled and categorized into four groups based on stenosis severity: minimal, mild, moderate, and severe.
  • Baseline characteristics, clinical laboratory indicators, and plasma CACNA2D1 protein concentrations were measured and compared across groups.
  • Statistical analyses were performed to determine correlations between CACNA2D1 levels and stenosis degree.

Main Results:

  • Plasma CACNA2D1 protein concentration demonstrated a significant upward trend with increasing coronary artery stenosis severity.
  • Concentrations ranged from 37.68 ng/mL in mild stenosis to 79.95 ng/mL in severe stenosis.
  • A clear positive correlation was observed between plasma CACNA2D1 levels and the degree of coronary artery stenosis.

Conclusions:

  • Plasma CACNA2D1 protein concentration is significantly correlated with the severity of coronary artery stenosis.
  • CACNA2D1 shows potential as a valuable biomarker for assessing coronary artery stenosis and aiding in early CHD detection.
Abstract

Keywords:
CACNA2D1calcium channel-encoding genecoronary heart disease (CHD)

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