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Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

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Updated: May 28, 2026

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images
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Published on: November 15, 2024

Quantification of Costal Cartilage Calcification Using 18F-NaF-PET/CT.

Vanessa Shehu1,2, Om H Gandhi1, Patrick Glennan1

  • 1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

Journal of Imaging
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

A new method quantifies costal cartilage calcification using 18F-sodium fluoride-positron emission tomography/computed tomography (18F-NaF-PET/CT). Calcification increases with age, particularly in males, and correlates with coronary artery calcification.

Keywords:
18F-sodium fluoride (18F-NaF)agingcalcificationcostal cartilagepositron emission tomography/computed tomography (PET/CT)

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Biomedical Engineering

Background:

  • Costal cartilage calcification quantification using 18F-NaF-PET/CT is not established.
  • The impact of aging and demographics on costal cartilage calcification is understudied.

Purpose of the Study:

  • Introduce a quantification methodology for costal cartilage calcification using 18F-NaF-PET/CT.
  • Assess age-related changes in 18F-NaF uptake in costal cartilage for both sexes.
  • Examine correlations between 18F-NaF uptake, CT attenuation, and coronary artery calcification.

Main Methods:

  • Retrospective analysis of 130 subjects from the CAMONA clinical trial.
  • Manual generation of regions of interest on costal cartilages (ribs 8-10, left side).
  • Non-parametric statistical analyses and ROC analysis for sex-specific age-related changes and correlations.

Main Results:

  • Significant positive correlation between 18F-NaF uptake and age in both females (r=0.36) and males (r=0.63), stronger in males.
  • Significant correlation between coronary artery calcium score and costal cartilage 18F-NaF uptake in both sexes.
  • Mean 18F-NaF uptake (SUVmean) was 0.69±0.38 in females and 0.63±0.22 in males.

Conclusions:

  • A novel quantification technique for costal cartilage calcification using 18F-NaF-PET/CT was developed.
  • Costal cartilage calcification increases with age, more significantly in males.
  • The technique shows potential for assessing cartilage calcification in various conditions.