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Updated: May 28, 2026
09:06
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
Research Progress on Marine Active Substances in Improving Atherosclerosis.
Chenyang Xie1,2, Jiapeng Qi2,3, Wenmei Huang4
1Engineering Technological Center of Mushroom Industry, School of Biological Science and Biotechnology, Minnan Normal University, Zhangzhou 363000, China.
Marine Drugs
|May 26, 2026
Summary
Marine natural products offer novel therapeutic avenues for atherosclerosis, a key factor in cardiovascular diseases. Research into these compounds aims to overcome limitations of current treatments and develop new drugs.
Area of Science:
- Marine Biology
- Pharmacology
- Medicinal Chemistry
Background:
- Atherosclerosis is a major pathological basis for cardiovascular and cerebrovascular diseases.
- Current treatments for atherosclerosis have limitations, including side effects and single-target mechanisms.
Purpose of the Study:
- To review marine-derived active substances with anti-atherosclerotic activity.
- To identify challenges in developing these substances into drugs.
- To provide a foundation for future anti-atherosclerotic drug development.
Main Methods:
- Literature review of research on marine-derived compounds.
- Analysis of their anti-atherosclerotic activities and mechanisms.
- Evaluation of current research challenges.
Main Results:
- Marine organisms produce secondary metabolites with diverse structures and activities.
- These metabolites show potential as novel anti-atherosclerotic agents.
- Significant challenges exist in drug development from marine sources.
Conclusions:
- Marine-derived compounds represent a promising source for novel anti-atherosclerotic drugs.
- Further research is needed to address challenges in isolation, characterization, and clinical translation.
- This review highlights the potential of marine natural products in combating atherosclerosis.
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