Tumor-Targeted Delivery Therapy Based on PLGA Nanoparticles.

Area of Science:

• Biomaterials Science
• Nanotechnology
• Oncology

Background:

• Poly(lactic acid-lactic acid) (PLGA) is a versatile biomaterial with excellent biocompatibility and degradability.
• PLGA nanoparticles (NPs) show promise for drug delivery due to their multifunctionality.
• Tumor-targeted drug delivery aims to increase drug concentration at the tumor site while minimizing systemic toxicity.

Purpose of the Study:

• To systematically review the physicochemical properties of PLGA materials for drug delivery.
• To summarize recent advances in tumor-targeting strategies utilizing PLGA NPs.
• To elucidate breakthroughs in PLGA-based delivery systems for enhanced cancer therapy.

Main Methods:

• Review of fundamental physicochemical properties of PLGA.
• Analysis of recent research on PLGA NP tumor-targeting strategies.
• Elucidation of stimulus-response mechanisms, passive targeting, active targeting, and combination immunotherapy.

Main Results:

• PLGA NPs can be engineered for targeted delivery via surface modifications and stimulus-responsive release.
• Strategies include passive targeting (EPR effect), active targeting (ligand-receptor interactions), and combination immunotherapy.
• Synergistic strategies are key to enhancing the targeting efficiency of PLGA-based systems.

Conclusions:

• PLGA NPs represent a promising platform for advanced tumor-targeted drug delivery.
• Further research into clinical translation and individualized oncology is crucial for precision nanomedicine.
• This review provides guidance for developing next-generation PLGA-based nanomedicines.