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Related Experiment Video

Updated: May 28, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
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Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Effectiveness of β-TriCalcium Phosphate for Alveolar Ridge Preservation: A Systematic Review.

Vitolante Pezzella1, Andrea Blasi1, Leopoldo Mauriello1

  • 1Department of Periodontology, School of Dental Medicine, University of Naples Federico II, 80131 Naples, Italy.

Journal of Functional Biomaterials
|May 26, 2026
PubMed
Summary

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Beta-tricalcium phosphate (β-TCP) shows variable results for alveolar ridge preservation (ARP). While sometimes less effective alone, β-TCP combined with other materials offers comparable outcomes to deproteinized bovine bone mineral (DBBM).

Area of Science:

  • Dentistry
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Alveolar ridge preservation (ARP) is crucial for mitigating post-extraction bone loss and enabling dental implant placement.
  • Beta-tricalcium phosphate (β-TCP) is an alloplastic graft material known for osteoconductivity and resorption.
  • Its clinical effectiveness in ARP requires further evaluation.

Purpose of the Study:

  • To systematically review the clinical effectiveness of β-TCP for alveolar ridge preservation.
  • To assess ridge dimensional changes using cone-beam computed tomography (CBCT).
  • To compare β-TCP outcomes with other bone grafting materials.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) published up to April 2026.
Keywords:
beta-tricalcium phosphatebone regenerationbone substitutescone–beam computed tomographyosteoconductiontooth extraction

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

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Last Updated: May 28, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

  • Inclusion criteria: CBCT-based dimensional outcomes reported at ≥4 months post-treatment.
  • Five RCTs were included, exhibiting heterogeneity in materials and methods.

    • Main Results:

    • β-TCP used alone yielded variable results, with some studies showing more resorption than xenografts.
    • When combined with other biomaterials, β-TCP demonstrated outcomes comparable to deproteinized bovine bone mineral (DBBM).
    • Significant heterogeneity in study designs and outcome assessments was noted.

    Conclusions:

    • β-TCP shows potential for alveolar ridge preservation, particularly in composite formulations.
    • Evidence is limited and heterogeneous, preventing definitive conclusions on its comparative predictability versus xenografts.
    • Further high-quality RCTs are necessary to establish optimal applications and clinical effectiveness.