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Radial Peripapillary Capillary Density Involved in Nasal Optic Disc Thinning and Visual Field Abnormalities Using

Miki Yoshimura1, Yuki Hashimoto1,2, Yuko Kodama2

  • 1Department of Orthoptics and Visual Sciences, Faculty of Health and Medical Sciences, Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan.

Tomography (Ann Arbor, Mich.)
|May 26, 2026
PubMed
Summary

Suspected nasal optic disc hypoplasia (NOH) may not always present with visual field defects, even with imaging evidence. Radial peripapillary capillary density differences, assessed by OCT angiography, may explain this variability in NOH patients.

Keywords:
circumpapillary retinal nerve fiber layer thicknesslaser speckle flowgraphymean blur rateoptical coherence tomography angiographyradial peripapillary capillary

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Area of Science:

  • Ophthalmology
  • Neuro-ophthalmology
  • Medical Imaging

Background:

  • Suspected nasal optic disc hypoplasia (NOH) is a condition that may affect visual function.
  • The presence and consistency of visual field abnormalities in suspected NOH require further investigation.

Purpose of the Study:

  • To investigate the presence of visual field abnormalities in eyes with suspected NOH.
  • To differentiate between NOH, pseudo-NOH (pNOH), and normal eyes using multimodal imaging.

Main Methods:

  • Diagnosis of NOH and pNOH based on optic disc appearance, visual field testing, and circumpapillary retinal nerve fiber layer (cpRNFL) thickness.
  • Utilized optical coherence tomography (OCT) for cpRNFL and nasal cpRNFL thickness, OCT angiography (OCTA) for radial peripapillary capillary (RPC) density, and laser speckle flowgraphy (LSFG) for optic disc blood flow velocity.

Main Results:

  • Reduced nasal cpRNFL thickness and mean blur rate (MBR) were observed in both NOH and pNOH groups compared to normal eyes.
  • Nasal RPC density was significantly lower in the NOH group than in the pNOH and normal groups.
  • Visual field abnormalities were not consistently present in suspected NOH cases.

Conclusions:

  • Visual field abnormalities are not consistently present in suspected NOH, despite imaging findings.
  • Reduced RPC density, assessed by OCTA, may be a distinguishing factor for NOH and contribute to functional variability.
  • Multimodal imaging approaches are crucial for a comprehensive evaluation of NOH.