Intention to Receive the TAK-003 Dengue Vaccine and Associated Factors Among Adults in Rural Northern Thailand

Background: Dengue is a common mosquito-borne disease in Thailand and poses an increased risk of severe illness among adults. The TAK-003 quadrivalent dengue vaccine is newly introduced in Thailand and has demonstrated promising efficacy. This study aimed to assess intention to receive the vaccine, knowledge, attitudes, and associated factors with TAK-003 among participants. Methods: A cross-sectional study was conducted from September 2024 to July 2025 among Thai adults aged ≥20 years living in rural areas of Chiang Mai. Individuals with prior dengue vaccination were excluded. Binary logistic regression identified factors associated with intention to the receive vaccine. Results: A total of 482 participants were enrolled. The mean age was 61.3 years (SD 11.5), and 73.2% (n = 353) were female. Most participants had primary education or lower (64.3%, n = 310), and 62.9% (n = 303) reported a monthly household income < 10,000 THB (314 USD). The intention to receive the TAK-003 vaccine was 68.7% (n = 331). Only 31.5-35.1% correctly answered dengue treatment questions, and 38.6% believed they would contract dengue within five years. Concerns regarding vaccine side effects (76.1%) and efficacy (56.4%) were common. Local healthcare providers were the most trusted source of vaccine information (78.0%), followed by doctors (49.2%). Prior influenza vaccination (aOR 1.57, 95% CI 1.02-2.41) and more positive attitudes toward dengue vaccination (aOR 1.06, 95% CI 1.02-1.10) were associated with intention to receive the vaccination. Conclusions: Intention to vaccinate with the TAK-003 vaccine among adults in rural Chiang Mai was moderate. These findings can inform community-based vaccination programs and strategic planning for dengue vaccine rollout in rural northern Thailand.