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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

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Related Experiment Video

Updated: May 28, 2026

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
07:42

A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas

Published on: June 5, 2014

Rv2656c: A Potential Candidate Antigen Associated with Latent Tuberculosis Infection.

Yunjie Du1, Pu He1,2, Wenrui Dang1

  • 1State Key Laboratory of Animal Disease Control and Prevention and Lanzhou Center for Tuberculosis Research, Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

Vaccines
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

Researchers identified Rv2656c, a latency-associated antigen, showing promise for a new tuberculosis (TB) vaccine. This antigen demonstrated immune protection and reduced bacterial load in preclinical models, offering potential for multi-stage TB subunit vaccines.

Keywords:
Mycobacterium bovisMycobacterium tuberculosislatency-associated antigenmetabolic enzymessecreted antigen

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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

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Published on: June 5, 2014

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Area of Science:

  • Immunology and Vaccinology
  • Infectious Diseases
  • Bioinformatics and Computational Biology

Background:

  • Existing tuberculosis (TB) subunit vaccines show limited efficacy due to narrow antigenic profiles and lack of latency antigens.
  • Identifying antigens effective during latent infection is crucial for developing improved TB vaccines.

Purpose of the Study:

  • To screen for and validate latency-associated antigens with immune-protective properties against TB.
  • To evaluate the immunogenicity and protective efficacy of candidate antigens in preclinical models.

Main Methods:

  • Bioinformatic screening of antigens highly expressed during latent infection models (hypoxia, nutritional starvation).
  • In silico prediction of physicochemical properties and immunogenicity.
  • Experimental validation in mycobacterium infection models, including intracellular cytokine detection, MGIA, ADCP, and a latent TB infection mouse model.

Main Results:

  • The antigen Rv2656c, highly expressed in nutritional starvation models, showed strong immunogenicity in humans and cattle.
  • Rv2656c significantly inhibited *Mycobacterium tuberculosis* and *Mycobacterium avium* growth in vitro.
  • Rv2656c enhanced macrophage phagocytosis and killing of mycobacteria, and reduced bacterial load in a latent TB mouse model.

Conclusions:

  • Latency-associated antigen Rv2656c exhibits significant immune-protective effects against TB.
  • Rv2656c holds potential as a key component for novel multi-stage antigen subunit vaccines against tuberculosis.