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Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity

Published on: June 25, 2015

Next-Generation Vaccines Leveraging T Cell-Centric Design, Mucosal Immunity, and Trained Innate Immunity for

Md Abdus Salam¹, Md Yusuf Al-Amin^2,3, Kasireddy Sudarshan²

¹Faculty of Biotechnology & Biomedical Engineering, Rajshahi Medical University, Rajshahi 6100, Bangladesh.

|May 26, 2026

Summary

Next-generation vaccines are advancing immunoprophylaxis by integrating T cell responses and trained innate immunity for durable, cross-protective effects against respiratory and enteric pathogens. These innovative platforms aim for enhanced protection beyond conventional vaccines.

Keywords:

T cell-centric design enteric pathogens mucosal immunity next-generation vaccines respiratory pathogens trained innate immunity

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Area of Science:

Immunology and Vaccinology
Infectious Disease Research
Next-Generation Therapeutics

Background:

Conventional vaccines often fail to induce durable or cross-protective immunity at mucosal surfaces.
Next-generation vaccines aim to overcome limitations of antibody-based approaches.
Respiratory and enteric pathogens pose significant global health challenges.

Purpose of the Study:

To explore the conceptual framework of next-generation vaccines.
To highlight progress in integrating adaptive and innate immune strategies.
To discuss challenges in translating novel vaccine platforms into clinical practice.

Main Methods:

Strategic antigen design for T cell engagement.
Mucosal immune engagement to enhance secretory IgA.
Induction of trained innate immunity via epigenetic and metabolic reprogramming.
Utilizing advanced delivery platforms like lipid nanoparticles and viral vectors.

Main Results:

Preclinical models show partial integration of adaptive and innate immune axes.
Potential for sterilizing immunity at mucosal surfaces and reinforced systemic protection.
Enhanced early pathogen control, reduced transmission, and defense against resistant pathogens.

Conclusions:

Next-generation vaccines integrating adaptive and innate immunity offer superior protection.
Human translation and validation of functional synergy require further clinical trials.
These platforms hold promise for enhanced defense against diverse and challenging infectious diseases.