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Updated: May 28, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
Integrative Therapies in Wound Healing in Small Animals: An Approach Beyond Traditional Medicine
Jorge Kauã Vila Real Sampaio Santos1, Esther Daniela de Sousa Costa1, César Carneiro Linhares Fernandes1
1Center of Health Science, University of Fortaleza, Fortaleza 60811-905, CE, Brazil.
Abstract:
The skin represents the largest organ in the body and functions to protect internal tissues from damage and infection. When wounds in small animals do not receive proper management, they may progress to chronic conditions, resulting in pain, delayed healing, and impaired well-being. Although conventional treatment mainly includes the use of topical antimicrobial agents and anti-inflammatory drugs, integrative veterinary medicine has been considered a promising complementary approach to enhance tissue repair. In this context, this study aimed to review non-conventional therapies applied to wound management in small animals, focusing on ozone therapy, light therapy that stimulates cellular activity, herbal medicine, and apitherapy, especially propolis. Overall, the analyzed studies indicate that ozone may contribute to microbial control and modulation of the immune response; light therapy may stimulate cellular activity and collagen production, promoting healing; medicinal plants present antioxidant and anti-inflammatory effects; and propolis demonstrates antimicrobial and regenerative properties. Thus, when responsibly applied and supported by scientific evidence, these approaches may complement conventional therapy, broaden clinical possibilities, and contribute to improved recovery and quality of life in animals.
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