Effect of Dietary α-Ketoglutarate Supplementation on the Performance, Gut Health, Gene Expression, Antioxidant Capacity, and Hematology in Broilers
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Published on: September 20, 2021
Hagar Elashry1, Husam H Nafea2, Ahmed Khalid Ahmed3,4
1Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Background:
Due to α-Ketoglutaric acid (AKG)'s anti-inflammatory and antioxidant properties, it may serve as a beneficial feed supplement for broilers. This study aimed to evaluate the impact of AKG supplementation in broiler diets on growth efficiency, blood indicators, and histological status.
Methods:
Two hundred sixteen unsexed, one-day-old broilers were randomly assigned to three experimental groups utilizing a completely randomized design. Each treatment was then subdivided into six replicates, each consisting of twelve chicks. In the experiment, the 1st group received a control (basal diet); the 2nd group received the basic diet supplemented with 0.5% AKG; and the 3rd group received the basal diet supplemented with 1.0% AKG.
Results:
The findings indicate that the addition of 0.5% and 1% AKG to broiler feed significantly (p < 0.05) improved BW, BWG, and FCR, particularly during the early stages of growth. The 0.5% AKG group had better feed efficiency and less FI, which means they grew faster and used nutrients better. AKG administration significantly (p < 0.05) increased TP and albumin levels in avian subjects, while simultaneously decreasing MDA and elevating CAT concentrations. Adding AKG to the broiler diet raises the levels of RBC, Hb, and PCV, but lowers RDW_CV. The results indicate that AKG lowers inflammation by raising IL-10 levels and lowering IL-1β levels. It also raises levels of antioxidant enzymes like SOD and CAT. Microscopic analysis revealed normal jejunal mucosa, submucosa, and muscular layers across all groups, including those receiving AKG supplements. The jejunal villus height, crypt depth, and their ratio were unchanged. The structure and function of the intestinal lining showed no significant changes when compared to the control.
Conclusions:
Adding AKG to broiler feed helps their growth, biochemical, and immune system indicators, but it does not hurt their histological conditions.
