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Updated: May 28, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
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Comparative Hepatic Transcriptomic Analysis Reveals Metabolic Regulatory Differences Between Qilian and Oula Sheep.

Yaxiong Ren1, Qi-Tala An1, Xiaohua Du1

  • 1College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.

Veterinary Sciences
|May 26, 2026
PubMed
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Qilian sheep exhibit distinct liver gene expression compared to Oula sheep, particularly in pathways for lipid and amino acid metabolism. This research identifies key genes and pathways for understanding breed-specific hepatic functions in cold-adapted sheep.

Area of Science:

  • Animal Genetics
  • Comparative Genomics
  • Metabolomics

Background:

  • Qilian sheep are an indigenous Tibetan breed adapted to harsh, high-altitude environments.
  • Understanding hepatic nutrient metabolism is crucial for optimizing livestock production and adaptation.

Purpose of the Study:

  • To compare liver transcriptomic profiles between Qilian sheep and Oula sheep.
  • To identify differentially expressed genes and pathways related to nutrient metabolism in Qilian sheep.

Main Methods:

  • Transcriptome sequencing of liver RNA from Qilian and Oula sheep.
  • Bioinformatic analysis including KEGG enrichment analysis.
  • Quantitative real-time PCR (qRT-PCR) for gene expression validation.

Main Results:

Keywords:
PPARlipidmetabolismplateauvalidationβ-oxidation

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  • 1640 differentially expressed genes were identified between the two sheep breeds.
  • Key pathways affected include lipid metabolism, amino acid metabolism, and fatty acid biosynthesis.
  • Eleven candidate genes were validated for their differential expression.

Conclusions:

  • Qilian and Oula sheep possess distinct hepatic gene expression patterns.
  • Differences are linked to lipid utilization, amino acid metabolism, and energy regulation.
  • Identified genes and pathways offer insights into breed-specific metabolic adaptations.