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When a PLC-γ1-based light switch tells a cell which way to go
Jichao Sun1,2, Mo Chen3,4
1Department of Critical Care Medicine, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
None:
Appalabhotla et al. (https://doi.org/10.1083/jcb.202507177) engineer a light-controlled version of PLC-γ1 (PLC-γ1) and show that activating it in an illuminated region of the cell membrane drives directional migration. The work redefines PLC-γ1 as an instructive signal in control of cell polarity.
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