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Updated: May 28, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
High-density lipoprotein cholesterol and cognitive function in patients undergoing hemodialysis
Kazuhiko Kato1,2, Akio Nakashima3, Chiharu Aizawa1,2
1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Clinical and Experimental Nephrology
|May 26, 2026
Summary
Higher high-density lipoprotein cholesterol (HDL-C) levels correlate with better cognitive function in older adults on hemodialysis. Low-density lipoprotein cholesterol (LDL-C) and triglyceride levels showed no significant association with cognitive scores in this patient group.
Area of Science:
- Nephrology
- Neurology
- Geriatrics
Background:
- Cognitive impairment is common in older adults undergoing maintenance hemodialysis.
- The underlying causes of cognitive decline in this population are not fully understood.
- Limited evidence exists on the relationship between lipid profiles and cognitive function in hemodialysis patients.
Purpose of the Study:
- To investigate the association between serum lipid profile components and global cognitive function.
- To address the evidence gap regarding lipids and cognition in maintenance hemodialysis patients.
Main Methods:
- An exploratory cross-sectional study was conducted with 265 participants (≥65 years) at seven Japanese dialysis centers.
- Serum levels of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were measured.
- Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE).
- Multivariate linear regression analyses were performed, adjusting for relevant clinical and nutritional factors.
Main Results:
- Higher serum HDL-C levels were independently associated with better scores on both MoCA and MMSE.
- Specifically, higher HDL-C correlated with improved global cognitive function in the fully adjusted model.
- Serum LDL-C and TG levels did not show significant associations with cognitive assessment scores.
Conclusions:
- Elevated serum HDL-C levels are linked to enhanced global cognitive function in elderly patients receiving maintenance hemodialysis.
- Serum LDL-C and TG levels were not found to be significantly related to cognitive performance in this cohort.
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