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Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Published on: June 13, 2014

Mechanically Regulated Nanozymes for Remote Metabolic Reprogramming and Precise Cancer Therapy.

Fangman Chen1,2, Xiaochun Xie3,4, Hanyao Huang3

  • 1Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China.

Angewandte Chemie (International Ed. in English)
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a mechanically regulated nanozyme (MRNZ) activated by ultrasound. This innovation enhances stem cell resilience and potentiates cancer therapy by precisely controlling reactive oxygen species generation.

Keywords:
cascade catalysismechanical forcemechanical regulationnanozymetumor therapy

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Catalysis

Background:

  • Mechanoenzymes regulate cellular processes, but artificial counterparts lack precise control.
  • Current nanozymes struggle with spatiotemporal regulation in biological settings.

Purpose of the Study:

  • To develop a mechanically regulated nanozyme (MRNZ) for precise control of catalytic activity.
  • To enhance stem cell therapy and cancer treatment through controlled reactive oxygen species generation.

Main Methods:

  • Integrating mechano-responsive ferrocene units into a flexible framework to create MRNZ.
  • Utilizing acoustic shear forces for mechanical activation and sub-nanostructural transformation.
  • Encapsulating glucose oxidase (GOx) within MRNZ to form a nanoreactor (MRNZ@GOx) for cascade reactions.

Main Results:

  • Mechanical activation via ultrasound precisely modulates peroxidase-like activity.
  • MRNZ enhances stem cell resilience to oxidative stress.
  • MRNZ@GOx potentiates chemodynamic therapy and immune activation in tumors via controlled ROS generation.

Conclusions:

  • Mechanically responsive nanozymes offer a novel strategy for precise biological catalysis.
  • This approach enables advanced remote and smart catalytic technologies for disease treatment.