Related Experiment Video
Updated: May 28, 2026
Profiling of Surface Protein Epitopes on Viral Particles by Multiplex Dual-Reporter Strategy
Published on: January 12, 2024
Decoding the complex receptor landscape of enterovirus D68
Mengyang Zhao1,2, Leiliang Zhang1,2
1Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Abstract:
Enterovirus D68 (EV-D68) is an emerging pathogen associated with severe respiratory diseases and central nervous system complications. This pearl summarizes the roles of glycan receptors, such as sialic acid, and protein receptors like ICAM-5 and MFSD6 in EV-D68 infection. MFSD6 serves as a primary receptor due to its widespread distribution in tissues, while sialic acid and ICAM-5 play a synergistic role in facilitating invasion across various tissues. We have elaborated on the correlation between receptor distribution, tissue tropism, and pathogenicity. The complex receptor system of EV-D68 enhances its pathogenicity by facilitating multi-tissue invasion and allowing the virus to adapt to various microenvironments. This adaptability provides insights into distinct receptor preferences and their associations with pathogenic outcomes, where specific receptor binding can influence the severity of infection. Additionally, we discuss the effectiveness of receptor-targeted inhibitors and the potential for therapeutic interventions aimed at disrupting receptor-virus interactions. Our pearl underscores the multifaceted nature of EV-D68 receptors and their implications for the development of novel antiviral strategies.
Insights
Enterovirus D68 (EV-D68) uses multiple receptors, including MFSD6, sialic acid, and ICAM-5, for infection. Understanding these viral entry mechanisms is key to developing new antiviral therapies against EV-D68.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- Enterovirus D68 (EV-D68) is an emerging viral pathogen causing severe respiratory and neurological diseases.
- Viral entry mechanisms are crucial for understanding EV-D68 pathogenesis and developing treatments.
Purpose of the Study:
- To elucidate the roles of specific glycan and protein receptors in EV-D68 infection.
- To correlate receptor distribution with EV-D68 tissue tropism and pathogenicity.
- To explore therapeutic strategies targeting EV-D68-receptor interactions.
Main Methods:
- Review and synthesis of existing literature on EV-D68 receptors.
- Analysis of the functional roles of sialic acid, ICAM-5, and MFSD6 in viral entry.
- Correlation of receptor expression patterns with clinical manifestations and disease severity.
Main Results:
- MFSD6 acts as a primary receptor for EV-D68 due to its broad tissue distribution.
- Sialic acid and ICAM-5 exhibit synergistic roles, facilitating viral invasion across diverse tissues.
- The complex interplay of these receptors enhances EV-D68 pathogenicity and adaptability.
Conclusions:
- EV-D68 employs a sophisticated receptor system, including MFSD6, sialic acid, and ICAM-5, to achieve multi-tissue invasion and adaptation.
- Understanding receptor-virus interactions is critical for predicting disease severity and developing targeted antiviral interventions.
- Targeting these specific receptors offers a promising avenue for novel therapeutic strategies against EV-D68 infections.
Related Concept Videos
01:28Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
01:27Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
01:15Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...