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Updated: May 28, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Photocatalytic Deacylative 1,2-Alkyl(hetero)arylation of Electron-Rich Styrenes
Subham Das1, Snehajit Chakraborty1, Christy Anna Varghese1
1School of Chemistry, Indian Institute of Science Education and Research Thiruvananthapuram, Thiruvananthapuram, Kerala 695551, India.
Abstract:
We report a mild photoredox-catalyzed deacylative three-component 1,2-alkyl(hetero)arylation of electron-rich styrenes with unstrained ketone-derived dihydroquinazolinones and electron-rich (hetero)arenes, showcasing high substrate compatibility under oxidative conditions. The radical-polar crossover blueprint uniquely integrates deacylative radical C(sp3)-C(sp3) bond formation with polar electrophilic aromatic substitution (SEAr)-driven C(sp3)-C(sp2) bond construction, overcoming competitive N-alkylation and E1-elimination. This method mostly offers a direct route to 1-aryl-1'-heteroarylalkanes and unsymmetrical 1,1-bis(heteroaryl)alkanes.
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