Related Experiment Video

Updated: May 28, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Lipoprotein(a) screening: Balancing benefits and challenges in clinical decision-making

Nolan Crain1

  • 1Nolan Crain is an assistant professor in the PA program at High Point University in High Point, NC. The author has disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|May 26, 2026
PubMed

Insights

Lipoprotein(a) (Lp(a)) is a key cardiovascular risk factor. Guidelines recommend Lp(a) testing for identifying individuals at high risk of atherosclerotic cardiovascular disease (ASCVD).

Area of Science:

  • Cardiology
  • Biochemistry
  • Genetics

Background:

  • Lipoprotein(a) (Lp(a)) is a significant independent risk factor for atherosclerotic cardiovascular disease (ASCVD).
  • Elevated Lp(a) levels contribute to ASCVD risk beyond traditional factors like LDL-C.
  • Major medical societies advocate for increased Lp(a) screening in adults.

Purpose of the Study:

  • To synthesize current knowledge on Lp(a).
  • To review Lp(a) biochemistry, pathophysiology, clinical significance, and assessment.
  • To discuss current and emerging management strategies for elevated Lp(a).

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of current clinical guidelines and recommendations.
  • Examination of laboratory assessment methods and therapeutic options.

Main Results:

  • Lp(a) is a well-established, independent ASCVD risk factor.
  • Guidelines support broader clinical implementation of Lp(a) testing.
  • Understanding Lp(a) aids in risk stratification and personalized prevention.

Conclusions:

  • Lp(a) testing is ready for wider clinical use.
  • Integrating Lp(a) assessment can improve cardiovascular risk identification.
  • Tailored interventions based on Lp(a) levels can enhance preventive cardiology strategies.

Keywords:
Lp(a)atherosclerosiscardiovascular risklipid managementlipoprotein(a)screening

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