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Updated: May 28, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Recognizing and managing neonatal sepsis.

Tucker Buffington¹, Lauren Hoover

¹Tucker Buffington practices pediatric critical care at Children's Hospital Colorado in Denver, CO. Lauren Hoover is academic director and a clinical assistant professor at the Mercer University PA program in Atlanta, GA. The authors have disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants

|May 26, 2026

Summary

This summary is machine-generated.

Neonatal sepsis is a major cause of newborn death globally. Understanding risk factors and evolving management strategies is crucial for healthcare providers to effectively recognize and treat this serious infection in infants.

Keywords:

antibiotic resistance intra-amniotic infection (IAI)intrapartum antibiotic prophylaxis (IAP)microbial cultures neonatal sepsis sepsis calculator

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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

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Published on: August 25, 2014

Area of Science:

Neonatology
Infectious Diseases
Pediatrics

Background:

Neonatal sepsis is a primary driver of infant morbidity and mortality worldwide.
Both early- and late-onset sepsis pose substantial risks, especially for premature and low birth weight infants.
Disease severity is influenced by pathogen virulence, host immunity, and exposure timing.

Purpose of the Study:

To underscore the importance of understanding neonatal sepsis.
To highlight the need for appropriate recognition and management by healthcare providers.
To emphasize the evolving landscape of diagnostic and therapeutic strategies.

Main Methods:

Review of current literature on neonatal sepsis.
Analysis of factors influencing sepsis progression.
Discussion of advancements in screening and treatment.

Main Results:

Neonatal sepsis continues to be a critical global health issue.
Effective management requires awareness of diverse influencing factors.
Ongoing advancements offer improved diagnostic and therapeutic potential.

Conclusions:

Healthcare providers must stay informed about neonatal sepsis.
Early recognition and prompt, appropriate management are vital for improving infant outcomes.
Continued evolution of screening and antibiotic strategies is essential.