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Therapy for Stage IV Non-Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, 2026.3.1
Lyudmila Bazhenova1, Nofisat Ismaila2, Greg Durm3
1University of California San Diego Moores Cancer Center, San Diego, CA.
Living guidelines provide continuously updated clinical practice recommendations for rapidly evolving fields. These guidelines ensure timely integration of new evidence by expert panels, aiding informed medical decisions.
Area of Science:
- Oncology
- Clinical Practice Guidelines
Background:
- Selected medical fields experience rapid evidence evolution.
- This necessitates dynamic updates to clinical practice recommendations.
Purpose of the Study:
- To describe the methodology and framework for developing and maintaining "living guidelines" in oncology.
- To outline the process for continuous literature review and guideline updates.
Main Methods:
- Systematic review of the health literature on a continuous basis by a standing expert panel.
- Development and adherence to established guidelines, including the ASCO Guidelines Methodology Manual and Conflict of Interest Policy.
Main Results:
- Living guidelines are updated on a regular schedule.
- Updates are published regularly and accessible online.
Conclusions:
- Living guidelines offer a mechanism for keeping clinical practice recommendations current in rapidly changing fields.
- These guidelines support, but do not replace, clinician judgment and patient-specific care.
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