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Related Concept Videos

Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...

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Updated: May 28, 2026

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
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Published on: October 13, 2023

Understanding and Managing Immunoglobulin A Nephropathy.

Kate K Romano1, Michael R Brodeur1, Darren W Grabe1

  • 1Albany College of Pharmacy and Health Sciences, Albany, New York.

Journal of Gerontological Nursing
|May 26, 2026
PubMed
Summary
This summary is machine-generated.

The 2025 Kidney Disease: Improving Global Outcomes (KDIGO) guideline offers updated strategies for Immunoglobulin A nephropathy (IgAN). It focuses on early diagnosis, risk assessment, supportive care, and targeted therapies to improve kidney outcomes.

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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
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Published on: July 8, 2020

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Last Updated: May 28, 2026

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
14:18

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

Published on: October 13, 2023

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Area of Science:

  • Nephrology
  • Immunology
  • Internal Medicine

Background:

  • Immunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerular disease globally.
  • IgAN is a significant contributor to chronic kidney disease (CKD) and end-stage renal disease (ESRD).

Purpose of the Study:

  • To review the 2025 Clinical Practice Guideline from Kidney Disease: Improving Global Outcomes (KDIGO) for IgAN management.
  • To summarize updated evidence-based diagnostic and therapeutic strategies for IgAN.

Main Methods:

  • Review of current literature on IgAN management.
  • Analysis of clinical evidence and existing guideline recommendations.
  • Synthesis of KDIGO 2025 guideline updates.

Main Results:

  • The 2025 KDIGO guideline prioritizes early biopsy-confirmed diagnosis and proteinuria-guided risk stratification.
  • Optimized supportive care, including strict blood pressure control and kidney-protective therapies, is emphasized.
  • Simultaneous use of novel therapies targeting pathogenic IgA and IgA-immune complexes is recommended.

Conclusions:

  • The 2025 KDIGO guideline promotes an interdisciplinary, multi-targeted approach to IgAN management.
  • The guideline aims to reduce proteinuria and preserve kidney function for improved long-term renal outcomes.
  • This evidence-based approach enhances the care of patients with IgAN.